Current Issue : July - September Volume : 2020 Issue Number : 3 Articles : 6 Articles
Bioactive glass (BG) was made by the solâ??gel method and doped with boron (B) to\nincrease its bioactivity. Microstructures of BG and B-doped BG were observed by scanning electron\nmicroscopy, and phase identification was performed using an X-ray diffraction diffractometer. The ion\nconcentrations released after soaking in simulated body fluid (SBF) for 1, 4, and 7 days were measured\nby inductively coupled plasma mass spectrometry, and the pH value of the SBF was measured\nafter soaking samples to determine the variation in the environment. Brunauerâ??Emmettâ??Teller\n(BET) analysis was performed to further verify the characteristics of mesoporous structures.\nHigh performance liquid chromatography was used to evaluate the drug delivery ability of teicoplanin.\nResults demonstrated that B-doped BG performed significantly better than BG in parameters assessed\nby the BET analysis. B-doped BG has nanopores and more rough structures, which is advantageous\nfor drug delivery as there are more porous structures available for drug adsorption. Moreover,\nB-doped BG was shown to be effective for keeping pH values stable and releasing B ions during\nsoaking in SBF. The cumulative release of teicoplanin from BG and B-doped BG reached 20.09% and\n3.17% on the first day, respectively. The drug release gradually slowed, reaching 29.43% and 4.83%\nafter 7 days, respectively. The results demonstrate that the proposed bioactive glass has potential\nas a drug delivery system....
Liposomes are extensively used in drug delivery, while alginates are widely used in tissue\nengineering. However, liposomes are usually thermally unstable and drug-leaking when in liquids,\nwhile the drug carriers made of alginates show low loading capacities when used for drug delivery.\nHerein, we developed a type of thermo-responsible liposomeâ??alginate composite hydrogel (TSPMAH)\nby grafting thermo-responsive liposomes onto alginates by using Ca2+ mediated bonding between\nthe phosphatidic serine (PS) in the liposome membrane and the alginate. The temperature-sensitivity\nof the liposomes was actualized by using phospholipids comprising dipalmitoylphosphatidylcholine\n(DPPC) and PS and the liposomes were prepared by a thin-film dispersion method. The TSPMAH\nwas then successfully prepared by bridge-linking the microcapsules onto the alginate hydrogel\nvia PS-Ca2+-Carboxyl-alginate interaction. Characterizations of the TSPMAH were carried out\nusing scanning electron microscopy, transform infrared spectroscopy, and laser scanning confocal\nmicroscopy, respectively. Their rheological property was also characterized by using a rheometer.\nCytotoxicity evaluations of the TSPMAH showed that the composite hydrogel was biocompatible, safe,\nand non-toxic. Further, loading and thermos-inducible release of model drugs encapsulated by the\nTSPMAH as a drug carrier system was also studied by making protamineâ??siRNA complex-carrying\nTSPMAH drug carriers. Our results indicated that the TSPMAH described herein has great potentials\nto be further developed into an intelligent drug delivery system....
Mefenamic acid fast disintegrating tablets were formulated by using sublimation method to reduce the bitter taste and first pass hepatic metabolism with a view to enhance patient compliance. Three different superdisintegrants viz., crospovidone, croscarmellose sodium and sodium starch glycolate were used in different ratios (6% and 12%) along with camphor, beta cyclodextrin, microcrystalline cellulose and saccharin sodium. Camphor is used as sublimating agent and saccharin sodium is used as taste masking agent. The formulated tablets were evaluated for post formulation parameters. FTIR studies indicate that the drug and excipients are compatible and also the stability studies indicate that there were no significant changes in the formulation....
The commercially available rebamipide ophthalmic suspension (CA-REB) was approved\nfor clinical use in patients with dry eye; however, the residence time on the ocular surface for the\ntraditional formulations is short, since the drug is removed from the ocular surface through the\nnasolacrimal duct. In this study, we designed a novel sustained-release drug delivery system (DDS) for\ndry eye therapy by rebamipide nanoparticles. The rebamipide solid nanoparticle-based ophthalmic\nformulation (REB-NPs) was prepared by a bead mill using additives......................
The intensive research is implemented within the ophthalmic drug delivery system to attain the far better drug products. For the treatment of eye alignment one amongst the foremost promising route of drug delivery is ophthalmic route. Within the modern pharmaceutical design controlled and sustained drug delivery has become the standard in order to overcome the problem related with the conventional eye drops. Within the sustained and controlled ophthalmic in-situ gelling system the quantity of the drug administered would be minimal and prolong the drug release by increasing the pre corneal retention time and their by increases the bioaccumulation. This work is focused on the establishment of the pH triggering ophthalmic in-situ gelling system of azithromycin by using mixture of polymers such as carbopol 934 as pH triggering polymer and guar gum as the viscosity enhancing agent all this polymers are utilized in distinct proportion together with the preservative benzalkonium chloride. The advance pH triggering in-situ gelling system are subjected for several evaluation test where the advance formulation show the sustained drug release over a period of 24 hours and establish to be sterile and nonirritant in nature....
Regarding compliance and minimization of side effects of nilotinib therapy, there is a medical\nneed to have a gastroretentive drug delivery system (GRDDS) to enhance the oral bioavailability\nthat is able to administer an optimal dose in a quaque die (QD) or daily manner. In this study,\nthe influence on a swelling and floating (sf ) GRDDS composed of a polymeric excipient (HPMC 90SH\n100K, HEC 250HHX, or PEO 7000K) and Kollidon....................
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